DNA synthesis plays a pivotal role in modern molecular biology, enabling scientists to engineer and manipulate DNA for various applications, including the cutting-edge field of information storage in DNA. At the heart of molecular biology lies the ability to synthesize custom DNA sequences with precision. These sequences serve as the genetic code that defines the traits of living organisms. The remarkable data storage potential of DNA has garnered significant attention in recent years. DNA molecules can store vast amounts of digital information in their chemical structure, offering a durable and compact storage medium that holds promise for long-term data archiving. However, unlocking this potential requires a deep understanding of DNA synthesis processes. While the field of DNA synthesis has witnessed tremendous advancements, it is essential to acknowledge the cost constraints associated with experimental approaches. Traditional DNA synthesis techniques, including Maskless Array Synthesis (MAS) and others, often demand substantial financial investments. These costs encompass equipment, reagents, operational expenses, and on-going maintenance, making them a barrier for many research projects. To address the cost challenges and make research in information storage in DNA more accessible and sustainable, simulation emerges as an attractive alternative. Simulators provide a cost-effective means of studying DNA synthesis processes, allowing researchers to model and experiment with various scenarios without the need for expensive physical equipment and materials. In this project, we have created a simulator tailored specifically for Maskless Array Synthesis (MAS). This simulator is intended to facilitate the study of MAS processes in the context of DNA storage research while alleviating the financial constraints associated with physical experimentation. Grounded in the latest research insights and findings, including those detailed in the study titled ”Chemical and photochemical error rates in light-directed synthesis of complex DNA libraries”, our MAS simulator represents a methodical effort to address the cost limitations. It provides a practical, cost-effective, and scalable solution for researchers engaged in the investigation of information storage in DNA through the MAS technique.
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